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Nuchal Thickening
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18 weeks a b  
  This fetus demonstrated nuchal thickening measuring 6 mm, a large pericardial effusion (*) that deviates the lung parenchyma posteriorly, and ascites at 18 weeks gestation. Infant had normal karyotype (assessed at birth).  
19 weeks c d d
     
c d d
Prominant nuchal thickening (measuring up to 11 mm) in a fetus with trisomy 21.
21 weeks c c c
  A fetus with 6 mm nuchal thickening and a normal karyotype.