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| Holoprosencephaly-associated midline facial cleft in a 17 week fetus. Note absence of midline tissue in the region of the lips and palate (arrow). |
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| Note absence of midline intracranial studies and hypotelorism. |
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| Sagittal and coronal sonograms of 18 week fetus with
complete bilateral cleft lip and palate (arrow). |
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| MR images of bilateral cleft lip and palate (arrows) corresponding to sonograms above.
Note on paramidline view that the soft palate is not visualized and the
tongue approaches the tissues of the nasopharynx. Also note the
protruding pseudomass (arrow on left image, between arrows on right image)
and nuchal thickening. |
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| 33 week fetus with acrocallosal syndrome and
right unilateral complete cleft lip with complete cleft palate. Sagittal view shows agenesis of the corpus callosum and a large midline cyst (c). Craniofacial abnormalities include unilateral cleft lip and the palate defect (arrow). Coronal view demonstrates absence of the corpus callosum. |
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| US of a 24 week fetus with isolated cleft lip (arrow). |
MRI of same fetus with cleft lip (black arrow) in the absence of cleft palate
(white arrow). Note that only the superficial soft tissue appears to be involved. Palate remains intact. |
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| Isolated cleft soft palate. The hard palate and upper lip were normal. Sonogram demonstrates severe micrognathia, but cleft soft palate was missed prospectively on both ultrasound and MRI. This could have been diagnosed prenatally if normal structure of the soft palate was noted. |
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| Note dysmorphic face, omphalocele, and enlarged cystic placenta of this fetus with Beckwith-Weidemann syndrome. |
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